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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Fig. 2

Fibrillar plaque and CD45 microglial expression in hippocampus. Representative pictures of thioflavine-S staining (fibrillar plaques) (top panels) and CD45 staining (microglia) (lower panels) at 7 (a) and 10 months (c). Scale bar: 50 um. (b) Image analysis of 7 month thioflavine-S (upper) and CD45 (lower) staining (Arctic n = 9, Arctic/C5aR1KO n = 9) (d) Image analysis of 10 mo thioflavine (Arctic n = 12, Arctic/C5aR1KO n = 9) (upper) and CD45 (Arctic n = 11, Arctic/C5aR1KO n = 7) lower). Bars represent group means +/− SEM of n animals per genotype. Data represent the average of 2 to 4 sections per animal. P value was calculated using one- way ANOVA

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Molecular Neurodegeneration

ISSN: 1750-1326