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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Hexokinases link DJ-1 to the PINK1/parkin pathway

Fig. 6

DJ-1 C106 is necessary for regulation of AKT. Primary DJ-1 knockout mouse astrocytes were transfected with LacZ-V5, wildtype DJ-1-V5, and C106A DJ-1-V5 and stimulated with IGF-1 for 5 min. a Immunocytochemistry for V5 (red), pAKT S473 (green), and total AKT (pink). Scale bar: 20 μm. b Quantification of pAKT S473 normalized to total AKT (n = 13 LacZ cells, n = 20 wildtype DJ-1 cells, n = 14 C106A DJ-1 cells). Groups were compared using One-way ANOVA followed by Bonferroni’s multiple comparison test

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Molecular Neurodegeneration

ISSN: 1750-1326