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Fig. 10 | Molecular Neurodegeneration

Fig. 10

From: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Fig. 10

Transgene-encoded human Tau is not expressed in a focal pattern in areas subject to focal staining in aged mice. Neuroanatomical areas prone to focal deposition in aged Tg mice were assessed before the onset of AT8-positive immunostaining. (a, c, e, g, i) non-Tg and (b, d, f, h, j) TgTauP301L mice (C57BL6/Tac background, ages 355 and 309 d, respectively) stained for tyrosine hydroxylase antibody in the locus coeruleus. The remaining panels indicate sections from different brain areas from non-Tg mice and Tg mice stained with using CP27 antibody, with Tg mice not exhibiting focal patterns of staining. c, d: locus coeruleus; e, f: corpus callosum; g, h: Pons; i, j: Hippocampus. All scale bars = 250 μm

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Molecular Neurodegeneration

ISSN: 1750-1326