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Fig. 11 | Molecular Neurodegeneration

Fig. 11

From: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Fig. 11

Presence of Tau protein in aged Tg animals with negative pathology. a Matching hemibrains of aged animals found lacking AT8 immunostaining (lanes 4–6, ages 723, 608, and 604 d respectively) were processed for western blot analysis and probed with antibody alongside young Tg mice (lanes 1–3, 66, 84 and 58d, respectively). Actin re-probe (lower panel) indicates similar sample loadings. b represents densitometric analyses of the blot data expressed normalized to actin and adjusted to C57BL/6Tac (“100%”). Aged pathology-negative Tg mice had more, rather than less, Tau than their young counterparts from the same inbred strain background, this reaching significance for the 129/SvEvTac and FVB/NJ backgrounds

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Molecular Neurodegeneration

ISSN: 1750-1326