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Fig. 12 | Molecular Neurodegeneration

Fig. 12

From: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Fig. 12

Insoluble Tau species in the brains of aged TgTauP301L mice. Fractionated brains comprising supernatant pellet 1 (SUP1), supernatant pellet 3 (SUP3), and pellet 3 (P3) of aged TgTau(P301L) mice were analyzed by western blot analysis. One example of Class I, II and IV is shown for each genetic background. a C57BL/6Tac mice at ages 587, 732, and 530 days left to right (b), 129/SvEvTac at ages 662, 592, and 466 days left to right, and (c) FVB/NJ mice at ages 646, 658, and 639 days left to right. For all samples, 10 μg of total protein was loaded on the gel. Antibody: CP13 (1/500; phosphoserine 202). SUP = Supernatant, and P = pellet fractions. d P3/S3 ratios of animals presented in A-C. Ratios were pooled across strain backgrounds. Class I vs. II p = 0.020; I vs IV, p = 0.08; II vs, IV, p = 0.003. e S1P fraction of animals with classes I, II and IV pathology to show the presence of oligomeric species in the soluble extract, antibody: CP27 (1/500)

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