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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Fig. 2

Presence of phosphorylated Tau species in fractioned brain of 90 and 240 days old mice from 3 genetic backgrounds. Half brains of TgTauP301L and non-Tg littermate controls were subjected to fractionation and presence of phosphorylated Tau species were investigated in different fractions. Inbred strains were investigated at 90 and 210–240 days of age, as indicated. a C57BL/6Tac, (b) 129/SvEvTac, and (c) FVB/NJ. For all samples, 10 μg of total protein was loaded on the gel. Antibody: CP13 (1/500; phosphoserine 202). SUP = Supernatant and P = pellet fractions

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