Fig. 4

Class I Tau pathology. Immunostaining with the phosphorylation-dependent anti-Tau antibody AT8 in the brain of TgTau mice illustrating the different patterns of deposition. Three different genetic backgrounds are represented C57BL/6 J (panels a to f); 129/SvEvTac (panels g to l) and FVB/NJ (panels m to r). Individual animals of each inbred strain presented here (and also in Figs.5-9) with the different antibody analyses shown in Figs. S2-S17 representing probing of closely adjacent sections from the same animals as Figs. 4-9. Several structures characteristic of the pattern of deposition are shown: while the frontal cortex is negative (panels a, g, m), the hippocampus (“Hpc”, panels b, c, h, i, n, o) exhibits GFT’s and occasional NFT’s, the caudate putamen (d, e, j, k, p, q) exhibits NFT’s while the Pons (panels f, l, r) is negative for immunostaining. Scale bar = 500 μm for panels b, h, and n. Scale bar = 250 μm for panels a, d, f, g, j, l, m, p, r. Scale bar = 50 μm for panels c, e, i, k, o and q