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Table 1 Pathology classes in TgTauP301L mice analyzed by genetic background

From: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

aGenetic background (n ♀, ♂)

bPathology Class average age in days ± SD (n♀, ♂)

I

II

III

IV

V

C57BL/6Tac (16,12)

c625 ± 90 (1,6)

c633 ± 60

(7,2)

c643 ± 77

(6,3)

472, 567

(1,1)

593

(1,0)

129/SvEvTac

(11,18)

504, 662

(0,2)

d666 ± 60

(5,7)

d647 ± 61

(3,4)

541 ± 56

(3,2)

607 ± 73

(0,3)

FVB/NJ

(12,15)

e583 ± 61

(2,8)

e597 ± 59

(3,3)

e615 ± 53

(5,2)

602 ± 102

(2, 2)

N/A

(0)

  1. Pathology classes were based upon the location of AT8 antibody immunostaining
  2. aC57BL/6Tac age-range = 451–758 days; 129/SvEvTac age-range = 466–733 days; FVB/NJ age-range = 451–678 days. Aged animals lacking pathology are not included in this Table but are described in the main text
  3. bAll pair-wise comparisons of mean age for classes I-IV with data pooled from three genetic backgrounds were not significant (n.s.)
  4. c,d,eAll pair-wise comparisons of mean age within a genetic background n.s
  5. Tg mice not present in the table include one C57BL/6Tac animal showing both class II and IV pathologies, one 129/SvEvTac animal showing both class III and IV pathologies while a further 27 animals did not fit within this classification scheme (12 C57BL/6Tac, 8129/SvEvTac and 7 FVB/NJ; see also Fig. 11)
  6. N/A, not applicable
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Molecular Neurodegeneration

ISSN: 1750-1326