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Table 1 Pathology classes in TgTauP301L mice analyzed by genetic background

From: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

aGenetic background (n ♀, ♂) bPathology Class average age in days ± SD (n♀, ♂)
I II III IV V
C57BL/6Tac (16,12) c625 ± 90 (1,6) c633 ± 60
(7,2) 		c643 ± 77
(6,3) 		472, 567
(1,1) 		593
(1,0)
129/SvEvTac
(11,18) 		504, 662
(0,2) 		d666 ± 60
(5,7) 		d647 ± 61
(3,4) 		541 ± 56
(3,2) 		607 ± 73
(0,3)
FVB/NJ
(12,15) 		e583 ± 61
(2,8) 		e597 ± 59
(3,3) 		e615 ± 53
(5,2) 		602 ± 102
(2, 2) 		N/A
(0)
  1. Pathology classes were based upon the location of AT8 antibody immunostaining
  2. aC57BL/6Tac age-range = 451–758 days; 129/SvEvTac age-range = 466–733 days; FVB/NJ age-range = 451–678 days. Aged animals lacking pathology are not included in this Table but are described in the main text
  3. bAll pair-wise comparisons of mean age for classes I-IV with data pooled from three genetic backgrounds were not significant (n.s.)
  4. c,d,eAll pair-wise comparisons of mean age within a genetic background n.s
  5. Tg mice not present in the table include one C57BL/6Tac animal showing both class II and IV pathologies, one 129/SvEvTac animal showing both class III and IV pathologies while a further 27 animals did not fit within this classification scheme (12 C57BL/6Tac, 8129/SvEvTac and 7 FVB/NJ; see also Fig. 11)
  6. N/A, not applicable
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Molecular Neurodegeneration

ISSN: 1750-1326