The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Table 2 Categorization of individual Tau filaments according to pathology classification and genetic background

Mouse lines	Pathology Class I				Pathology Class II				Pathology Class IV
		Filament Types				Filament Types				Filament Types
	N	Straight Filament	Coiled Filament	Twisted Ribbon-like Filament	N	Straight Filament	Coiled Filament	Twisted Ribbon-like Filament	N	Straight Filament	Coiled Filament	Twisted Ribbon-like Filament
C57BL/6	2	39	35	1	2	189	0	0	2	6	0	0
C57BL/6	2	52%	47%	1%	2	100%	0%	0%	2	100%	0%	0%
129SvEv	1	22	0	1	1	55	0	0	3	23	0	0
129SvEv	1	96%	0%	4%	1	100%	0%	0%	3	100%	0%	0%
FVB/NJ	2	21	0	0	3	121	1	0	3	14	0	0
FVB/NJ	2	100%	0%	0%	3	99%	1%	0%	3	100%	0%	0%

Negative stain electron microscopy was used to distinguish the different morphologies of isolated Tau filaments (Fig. 14). Filaments numbers were totaled for animals of the same Class and inbred strain type. N, number of animals analyzed

ISSN: 1750-1326