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Table 2 Categorization of individual Tau filaments according to pathology classification and genetic background

From: The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Mouse lines Pathology Class I Pathology Class II Pathology Class IV
  Filament Types   Filament Types   Filament Types
N Straight Filament Coiled Filament Twisted Ribbon-like Filament N Straight Filament Coiled Filament Twisted Ribbon-like Filament N Straight Filament Coiled Filament Twisted Ribbon-like Filament
C57BL/6 2 39 35 1 2 189 0 0 2 6 0 0
52% 47% 1% 100% 0% 0% 100% 0% 0%
129SvEv 1 22 0 1 1 55 0 0 3 23 0 0
96% 0% 4% 100% 0% 0% 100% 0% 0%
FVB/NJ 2 21 0 0 3 121 1 0 3 14 0 0
100% 0% 0% 99% 1% 0% 100% 0% 0%
  1. Negative stain electron microscopy was used to distinguish the different morphologies of isolated Tau filaments (Fig. 14). Filaments numbers were totaled for animals of the same Class and inbred strain type. N, number of animals analyzed
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Molecular Neurodegeneration

ISSN: 1750-1326