Skip to main content
Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases

Fig. 2

Comparison of the 5′-UTR IRE stem-loop of the α-Syn, APP, H-ferritin and L-ferritin transcripts. a Stem-loop structures of α-Syn, APP, H-ferritin and L-ferritin. b Relative alignment of the sequences encoding the 5′-UTR-specific IRE stem-loops in α-Syn, APP, H-ferritin and L-ferritin. The key IRE motifs of AGU or AGA are highlighted in purple. B. Homological analysis of the IRE stem-loop sequences of the α-Syn, APP, H-ferritin and L-ferritin transcripts. Key IRE motifs are highlighted in yellow, while homological nucleotides in the flank areas of the key IRE motifs are highlighted in cyan. c Maps of the 5′-UTR IRE stem-loops in the α-Syn, APP, H-ferritin and L-ferritin transcripts

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326