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Table 1 The region-specific oligodendrocyte-enriched gene networks are among the top associated functional coexpression modules with the 543 significant Alzheimer’s disease GWAS hits

From: Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Module Name Enriched Cell Type Enriched GO Term Size Shared P-Value Adjusted
P-Value
Light cyan Microglia Immune functions 559 23 1.91e-05 0.00118
Green Oligodendrocyte Nerve ensheathment 1098 32 0.000389 0.0121
Purple Neuron Synaptic transmission 847 26 0.000636 0.0131
Gold Microglia Immune functions 400 14 0.00352 0.0546
Salmon Neuron Synaptic transmission 750 21 0.00582 0.0722
Burlywood Ependymal Cell Dynein complex 114 6 0.008 0.0806
Magenta Astrocyte Cell adhesion 841 22 0.0103 0.0806
Gray 1 None Cell junction 56 4 0.0104 0.0806
Light green Oligodendrocyte Nerve ensheathment 474 14 0.0145 0.0998
Seashell None Coated vesicle 313 10 0.0222 0.127
Black None Neuropeptide hormone 1067 25 0.0226 0.127
Tan Mural Cell Extracellular matrix 734 18 0.033 0.171
Blue Astrocyte Cadherin 1508 31 0.0557 0.247
Yellow Microglia Immune functions 1174 25 0.058 0.247
Honey dew Astrocyte Muscle contraction 139 5 0.0613 0.247
Medium blue None NAD(P) homeostasis 233 7 0.066 0.247
Red 4 Ependymal Cell Transport 62 3 0.0682 0.247
Red Oligodendrocyte Nerve ensheathment 1089 23 0.0717 0.247
Gold 3 Ependymal Cell Dynein complex 71 3 0.0936 0.294
Peru Neuron Synaptic transmission 408 10 0.095 0.294
  1. The 20 modules with the strongest Fisher’s Exact Test enrichment in AD GWAS genes from the IGAP data set of the 62 multiscale coexpression modules with at least 50 members were considered. P-values were adjusted via the Benjamini-Hochberg method. Size = the number of genes in the module, Shared = the number of overlaps between the IGAP AD GWAS genes and the coexpression modules, GO = Gene Ontology