Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Table 1 The region-specific oligodendrocyte-enriched gene networks are among the top associated functional coexpression modules with the 543 significant Alzheimer’s disease GWAS hits

Module Name	Enriched Cell Type	Enriched GO Term	Size	Shared	P-Value	Adjusted P-Value
Light cyan	Microglia	Immune functions	559	23	1.91e-05	0.00118
Green	Oligodendrocyte	Nerve ensheathment	1098	32	0.000389	0.0121
Purple	Neuron	Synaptic transmission	847	26	0.000636	0.0131
Gold	Microglia	Immune functions	400	14	0.00352	0.0546
Salmon	Neuron	Synaptic transmission	750	21	0.00582	0.0722
Burlywood	Ependymal Cell	Dynein complex	114	6	0.008	0.0806
Magenta	Astrocyte	Cell adhesion	841	22	0.0103	0.0806
Gray 1	None	Cell junction	56	4	0.0104	0.0806
Light green	Oligodendrocyte	Nerve ensheathment	474	14	0.0145	0.0998
Seashell	None	Coated vesicle	313	10	0.0222	0.127
Black	None	Neuropeptide hormone	1067	25	0.0226	0.127
Tan	Mural Cell	Extracellular matrix	734	18	0.033	0.171
Blue	Astrocyte	Cadherin	1508	31	0.0557	0.247
Yellow	Microglia	Immune functions	1174	25	0.058	0.247
Honey dew	Astrocyte	Muscle contraction	139	5	0.0613	0.247
Medium blue	None	NAD(P) homeostasis	233	7	0.066	0.247
Red 4	Ependymal Cell	Transport	62	3	0.0682	0.247
Red	Oligodendrocyte	Nerve ensheathment	1089	23	0.0717	0.247
Gold 3	Ependymal Cell	Dynein complex	71	3	0.0936	0.294
Peru	Neuron	Synaptic transmission	408	10	0.095	0.294

The 20 modules with the strongest Fisher’s Exact Test enrichment in AD GWAS genes from the IGAP data set of the 62 multiscale coexpression modules with at least 50 members were considered. P-values were adjusted via the Benjamini-Hochberg method. Size = the number of genes in the module, Shared = the number of overlaps between the IGAP AD GWAS genes and the coexpression modules, GO = Gene Ontology

ISSN: 1750-1326