Fig. 1

Whole genomic locus MAPT H1/H2 vectors capture over 86% sequence diversity. a Common SNPs as registered on the dbSNP b144 database identified between the H1 and H2 pMAPT vectors. b Schematic representation of the H1/H2 pMAPT genomic features. The H1 and H2 MAPT vector sequences start and end at the same point, and are not different between H1 and H2 except at the sites of haplotype-specific variation. The H1 and H2 sequences are comprised of promoter (coloured arrow), introns and exons (filled boxes and numbered), and 3′ untranslated region (3’UTR) and downstream sequences to include two polyadenylation sites (Poly (A)). (HA: haemagglutinin sequence, black arrow: transcription start, unfilled boxes: untranslated exons). c Schematic representation of the pMAPT vector. The MAPT sequence is ~143 kb. (lacZ: β-galactosidase gene, amp^r and kan^r: ampicillin and kanamycin resistance)