Fig. 1

Activation of the NADPH oxidase family members. The figure illustrates for each NADPH oxidase the catalytic core region (in blue), the transmembrane maturation and stabilization subunits (in red) as well as the cytosolic subunits and the small GTPases (Rac1 and Rac2). The predicted regions for FAD and NADPH binding sites and the putative peroxidase-like region are also shown, as well as the EF hand motifs (yellow circles) that bind to Ca²⁺