Fig. 2
From: YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias
YKL-40 expression in sCJD brain tissue. a Immunohistochemical analysis for detection of YKL-40 in the cerebral cortex and white matter of control and sCJD cases. b Immunohistochemical analysis of YKL-40 in the cerebellum of control and sCJD cases. Brown staining corresponds to YKL-40 staining and light blue to haematoxylin counterstaining. c Immunofluorescence analysis of YKL-40 (green) and GFAP (red) in cerebral cortex region of sCJD. Nuclei were stained with DAPI (blue). d Correlation between the expression levels of YKL-40 and GFAP mRNA (left panel) or AIF-1 mRNA (right panel) in the frontal cortex of sCJD cases. Normalization was performed using GAPDH. Pearson test was used to determine the correlations between mRNA expression levels