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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: A validated antibody panel for the characterization of tau post-translational modifications

Fig. 8

Human entorhinal cortex (EC) lysates show many but not all tau PTMs. a-e Immunoblots demonstrate strong reactivity of all pan-tau antibodies with human EC (n = 3). f-i detection with isoform specific tau antibodies reveals the presence of multiple isoforms of tau. TL: recombinant tau ladder. j-t PTM-specific antibodies demonstrate reactivity except for j nY18, k AcK280, n pT212, p pS238 and t pS422. u Immunoblotting with actin for loading control shows similar loading for three different EC lysates (n = 3). v kDa sizes for the marker

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