Fig. 7

Exclusive DEPs in ADLP^APT mice and their related functional networks. a Proteins that were significantly altered in early or late ADLP^APT mice (Student’s t-test p-value <0.05 and fold-change >1.25) but not in the other models (fold change <1.25) were selected as exclusive DEPs^APT. b The biological functions derived from the GO analysis are shown along with their networking with associated proteins. c The knowledge database-derived protein network of App, Mapt, and exclusive DEPs^APT. The fold-change values of individual protein nodes were visualized in color circles (blue: down-regulation, red: up-regulation). The color of the inner circle is the fold-change of the 4-month ADLP^APT mouse, and the color of the outer circle represents that of the 10-month ADLP^APT mouse. d Three proteins that form bridge between App and Mapt (Hcls1, Ptprc and Abca1) were validated by western blot analysis. Representative western blot images are shown herein. The expression levels of the proteins are quantified compared with wild type mice (n = 3 per genotype for 4 and 10 months; Student’s t test). Results are expressed as the mean ± SEM. **P < 0.01; ***P < 0.001