Fig. 2

Mfn2 ablation caused mitochondrial fragmentation and ultrastructural damage in the hippocampus in vivo as evidenced by electron microscopic analysis. a Representative electron micrographs of CA1 neuron from hippocampus of control (28-week-old) (upper left) and Mfn2 cKO at different ages as indicated. b Quantification of aspect ratio demonstrated significant mitochondrial fragmentation in 8 and 28 week old Mfn2 CKO mice. c Quantification of mean area of mitochondria demonstrated significantly enlarged mitochondrial size in 28 week old Mfn2 cKO mice compared to control mice. Data are means ± SEM Student’s t-test, *P < 0.05