Fig. 1

Effects of a control diet, a moderate high-fat diet (45% kcal from fats, HF45), and a very high-fat diet (60% kcal from fats, HF60) administered to male Wistar rats from the age of two months until the age of six months on working memory using spontaneous alternation paradigm in a T-maze. Food in HF groups was offered in isocaloric amounts to the NF group (control). Five trials per rat were performed and then % alternation was calculated per group. Data represent mean ± SD (n = 7). Statistics: * indicates that values from the HF groups are different from the control group (Student’s t test, p < 0.05). Additionally, a one-way ANOVA was performed followed by an LSD post hoc test; values not sharing a common letter (a, b) are significantly different (p < 0.05)