Fig. 3
From: Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
Localization of phosphotau immunoreactivity versus G85R-SOD1:YFP pathology in bigenic JNPL3/G85R-SOD1:YFP animals. Hyperphosphorylated human tau pathology recognized by the PHF1 (Ser396/Ser404; red) antibody appears similar in JNPL3 tau-transgenic versus JNPL3/G85R-SOD1:YFP bigenic mice (a, b). G85R-SOD1:YFP pathology, detected using an YFP antibody (green) (c), does not robustly co-localize with tau pathology in double transgenic animals (d). Nuclei were stained with DAPI (blue). Images are of 60× magnification within the ventral horn of the spinal cord of JNPL3 and JNPL3/G85R-SOD1:YFP mice. The images shown are representative of 8 JNPL3 and 8 JNPL3/G85R-SOD1:YFP female animals aged 7 to 15.5 months