Fig. 9
From: AMPA-ergic regulation of amyloid-β levels in an Alzheimer’s disease mouse model
Model of AMPA-R-mediated Aβ regulation. a Tonic, steady-state AMPA-R activity driven by spontaneous neurotransmission increases levels of Aβ in the ISF. b Evoked glutamatergic transmission resulting from AMPA treatment initially decreases ISF Aβ through NMDA-R activation. As described in previous studies, NMDA-Rs lead to decreased Aβ production and release into the ISF through ERK phosphorylation and enhanced α-secretase activity. c Extended AMPA-R activation, independent of NMDA-Rs, increases IL-6 signaling to stimulate clearance of Aβ from the ISF