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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Fig. 3

Pathway enrichments for the BDNF, dopamine receptor, glucocorticoid receptor pathways after pridopidine treatment. Each box shows the Adj. p-val for either the BDNF, dopamine D1 receptor (D1R), or glucocorticoid (GR) pathway in a given treatment, genotype, and tissue. Consistent with the gene level results from the RNAseq data, the pathway signal is most consistent in the WT and YAC128 striatum after treatment with pridopidine. “High” = 30 mg/kg of pridopidine; “Low” = 10 mg/kg of pridopidine; “Veh” = vehicle. Grey = no enrichment. Red = significant positive enrichment. Blue = significant negative enrichment

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Molecular Neurodegeneration

ISSN: 1750-1326