Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Table 1 Summary of genes with differential expression or alternative junction/exon usage

Number of Differentially Expressed Genes
Contrast	Striatum	Hippocampus	Cortex
YAC128 Veh-WT Veh	1346	340	7
YAC128 10 mg/kg-YAC128 Veh	73	0	0
YAC128 30 mg/kg-YAC128 Veh	221	0	0
WT 30 mg/kg-WT Veh	17	0	0
Number of Genes with Alternative Junction/Exon usage
YAC128 Veh-WT Veh	39	14	4
YAC128 10 mg/kg-YAC128 Veh	1	0	0
YAC128 30 mg/kg-YAC128 Veh	565	1	4
WT 30 mg/kg-WT Veh	0	4	2

An Adj. p-val cutoff of 0.05 was used as pre-requisite criterion to identify differentially expressed genes (top) and alternative exon/junction usage cases (bottom) for each contrast and each tissue

ISSN: 1750-1326