From: Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration
Drug
PPARγ binding IC 50 (μM)
MPC binding (μM)
C max /half life
Rosiglitazone
0.112
1.1
1 µM/3–4 h
Pioglitazone
1.535
1.2
4 µM/5–8 h
MSDC-0160
31.648
12 µM/12 h