Fig. 2
From: The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease
Plaque-associated myeloid cells are reduced in mice expressing the Trem2 R47H variant. a Immunohistochemistry was used to quantify the number of myeloid cells (IBA1, green) around plaques (6E10, blue). b Cells expressing high levels of CD45 (magenta) around plaques (6E10, blue) were identified by immunohistochemistry and the percent CD45-positive area per plaque was quantified. c Proliferating (Ki67-positive, red) myeloid cells (IBA1-positive, green) were quantified across the entire cortex and hippocampus from one medial and one lateral section. Data from APPPS1–21; Trem2+/+ (n = 8), APPPS1–21;Trem2+/− (n = 8), and APPPS1–21;Trem2+/R47H (n = 10) mice are represented as mean ± SEM. *p < 0.05; ** p < 0.01; ***p < 0.001; ns - not significant. Representative images are from the cortex