Fig. 5
From: Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency
Tmem106b Reduction Suppresses Activity of β-Glucuronidase. Tmem106b reduction had no significant effect on LAMP-1 levels (a) or GCase activity (c) in the frontal cortex of 2- to 5-month-old mice. HexA activity was significantly reduced in Tmem106b+/− mice (b, ANOVA effect of Tmem106b, p = 0.0175, ** = p = 0.0095 by Dunnett’s post-hoc test). Gusb activity was significantly reduced in both Tmem106b+/− and Tmem106b−/− mice (d, ANOVA effect of Tmem106b, p = 0.0007, ** = p < 0.01, *** = p < 0.001 by Dunnett’s post-hoc test). n = 6–7 mice per genotype