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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling

Fig. 3

Chronic insulin administration reduces the Aβ42/40 ratio in the conditioned media of BFCNs harboring FAD mutations. ELISA quantification of iPSC derived basal cholinergic neurons measuring amyloid β. Cells (DIV 34) were insulin deprived for 3 days or given 1000 ng/mL every 24 h for 3 days. Aβ 40 (a), Aβ 42 (b), and Aβ 42/40 (c) measured in collected media. These data correspond to results of 2 independent experiments. * P < 0.05; ** P < .01

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Molecular Neurodegeneration

ISSN: 1750-1326