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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Fig. 5

PU.1-regulated proteins demonstrate microglial expression in the human AD brain. NanoString gene expression analysis of selected microglial genes reveals induction of (a) SPI1 (p < 0.001), (b) TYROBP (p < 0.001), (c) HLA-DRA (p < 0.001), (d) TREM2 (p < 0.05), (e) PTPRC (p < 0.001), and (f) AIF1 (p < 0.01) in human brain MFG tissue derived from neurologically normal (n = 8) or clinically and pathologically confirmed AD tissue (n = 8). Representative images demonstrating microglial localisation of (g) DAP12, (h) HLA-DR, DP, DQ, (i) TREM2, and (j) CD45 with IBA1 in the control and AD brain. Scale bar = 200 μm, inset = 20 μm. * = p < 0.05, ** = p < 0.01, *** = p < 0.001, Students t test

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