Fig. 3
From: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis
Delayed onset of RGC differentiation in Nrf1f/f;Six3-Cre retina. (a–f) Immunostaining of wildtype (a, c, and e) and Nrf1f/f;Six3-Cre (b, d, and f) retinas. (a, b) E12.5 retinal sections labeled with anti-Isl1 antibody. (c, d) E14.5 and (e, f) E16.5 retinal sections labeled with anti-Pou4f2 antibody. Arrowheads indicate clumped Pou4f2+ cells in the central area of Nrf1f/f;Six3-Cre retina. Scale bars: 50 μm in a–d, 100 μm in e and f. WT: wildtype