Fig. 3

Functional analysis of the proteomic data obtained comparing early versus late disease stage. The longitudinal analysis was undertaken using the list of total regulated proteins (FC 1.3, p value < 0.05) in slow and fast progressing ALS individuals independently. Pathways with a p value < 0.05 were considered significantly enriched and plotted with a - log 10 transformed p value in descending order of statistical significance. Functional analysis was performed for Reactome pathways, if not otherwise specified. Only pathways with the highest enrichment were reported among redundant pathways. Significantly enriched pathways in slow progressing patients (a), in fast progressing patients (c) and shared by slow and fast progressing patients (b)