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Table 2 Regulated proteins in fast compared to slow progressing ALS patients in the early disease stage

From: Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

 

Protein ID

Protein Descriptions

Gene Name

Peptide #

Early _Fast/Early Slow Log Fold Change

adjusted p-value

Up regulated in FAST.

Early stage.

P05106

Integrin beta-3

ITGB3

2

2.224407

0.001111

O95810

Serum deprivation-response protein

SDPR

3

2.102

0.001403

H7BYX6

Isoform of P13591, Neural cell adhesion molecule 1

NCAM1

2

2.027403

0.000418

P04003

C4b-binding protein alpha chain

C4BPA

7

2.013732

8.04E-05

P07437

Tubulin beta chain

TUBB

2

1.908567

0.00790

P63173

60S ribosomal protein L38

RPL38

2

1.727873

0.00652

Q14697

Neutral alpha-glucosidase AB

GANAB

2

1.638215

0.00134

P02649

Apolipoprotein E

APOE

9

1.513701

8.53E-05

P36957

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

DLST

2

1.487187

0.00960

A0A0A0MR02

Isoform of P45880, Voltage-dependent anion-selective channel protein 2

VDAC2

4

1.4397

0.00229

P05090

Apolipoprotein D

APOD

6

1.293627

0.00240

P80723

Brain acid soluble protein 1

BASP1

4

1.220442

0.00111

P15169

Carboxypeptidase N catalytic chain

CPN1

3

1.17725

0.00616

Q06033–2

Isoform of Q06033, Isoform 2 of Inter-alpha-trypsin inhibitor heavy chain H3

ITIH3

4

1.176924

0.00172

P48740–2

Isoform of P48740, Isoform 2 of Mannan-binding lectin serine protease 1

MASP1

2

1.126878

0.00134

P35527

Keratin, type I cytoskeletal 9

KRT9

6

1.061453

0.00827

Q15582

Transforming growth factor-beta-induced protein ig-h3

TGFBI

3

1.026849

0.00652

P07355

Annexin A2

ANXA2

6

1.021165

0.00788

Down regulated in FAST

Early stage.

P69905

Hemoglobin subunit alpha

HBA1

6

−1.12687

0.00682

E7ETH0

Isoform of P05156, Complement factor I

CFI

3

−1.14553

0.00190

O75636–2

Isoform of O75636, Isoform 2 of Ficolin-3

FCN3

4

−1.16238

0.00616

Q96IY4

Carboxypeptidase B2

CPB2

2

−1.23801

0.00134

P05452

Tetranectin

CLEC3B

2

−1.32297

0.00173

P30050

60S ribosomal protein L12

RPL12

2

−1.50426

0.00172

P20700

Lamin-B1

LMNB1

2

−1.86089

0.00728

P00505

Aspartate aminotransferase, mitochondrial

GOT2

2

−2.47293

0.00172

P02042

Hemoglobin subunit delta

HBD

3

−2.49876

0.00040

Q5T123

Isoform of Q9H299, SH3 domain-binding glutamic acid-rich-like protein 3

SH3BGRL3

2

−2.75577

0.0011

  1. Only proteins identified with at least two unique peptides are shown. Up-regulated proteins are shown in the upper part of the table (grey), with Integrin beta-3 showing the highest fold change. Down-regulated proteins are shown in the bottom part of the table (light blue), with Isoform of Q9H299, SH3 domain-binding glutamic acid-rich-like protein 3, showing the highest fold change of all down-regulated proteins
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Molecular Neurodegeneration

ISSN: 1750-1326