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Table 2 Regulated proteins in fast compared to slow progressing ALS patients in the early disease stage

From: Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

  Protein ID Protein Descriptions Gene Name Peptide # Early _Fast/Early Slow Log Fold Change adjusted p-value
Up regulated in FAST.
Early stage.
P05106 Integrin beta-3 ITGB3 2 2.224407 0.001111
O95810 Serum deprivation-response protein SDPR 3 2.102 0.001403
H7BYX6 Isoform of P13591, Neural cell adhesion molecule 1 NCAM1 2 2.027403 0.000418
P04003 C4b-binding protein alpha chain C4BPA 7 2.013732 8.04E-05
P07437 Tubulin beta chain TUBB 2 1.908567 0.00790
P63173 60S ribosomal protein L38 RPL38 2 1.727873 0.00652
Q14697 Neutral alpha-glucosidase AB GANAB 2 1.638215 0.00134
P02649 Apolipoprotein E APOE 9 1.513701 8.53E-05
P36957 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial DLST 2 1.487187 0.00960
A0A0A0MR02 Isoform of P45880, Voltage-dependent anion-selective channel protein 2 VDAC2 4 1.4397 0.00229
P05090 Apolipoprotein D APOD 6 1.293627 0.00240
P80723 Brain acid soluble protein 1 BASP1 4 1.220442 0.00111
P15169 Carboxypeptidase N catalytic chain CPN1 3 1.17725 0.00616
Q06033–2 Isoform of Q06033, Isoform 2 of Inter-alpha-trypsin inhibitor heavy chain H3 ITIH3 4 1.176924 0.00172
P48740–2 Isoform of P48740, Isoform 2 of Mannan-binding lectin serine protease 1 MASP1 2 1.126878 0.00134
P35527 Keratin, type I cytoskeletal 9 KRT9 6 1.061453 0.00827
Q15582 Transforming growth factor-beta-induced protein ig-h3 TGFBI 3 1.026849 0.00652
P07355 Annexin A2 ANXA2 6 1.021165 0.00788
Down regulated in FAST
Early stage.
P69905 Hemoglobin subunit alpha HBA1 6 −1.12687 0.00682
E7ETH0 Isoform of P05156, Complement factor I CFI 3 −1.14553 0.00190
O75636–2 Isoform of O75636, Isoform 2 of Ficolin-3 FCN3 4 −1.16238 0.00616
Q96IY4 Carboxypeptidase B2 CPB2 2 −1.23801 0.00134
P05452 Tetranectin CLEC3B 2 −1.32297 0.00173
P30050 60S ribosomal protein L12 RPL12 2 −1.50426 0.00172
P20700 Lamin-B1 LMNB1 2 −1.86089 0.00728
P00505 Aspartate aminotransferase, mitochondrial GOT2 2 −2.47293 0.00172
P02042 Hemoglobin subunit delta HBD 3 −2.49876 0.00040
Q5T123 Isoform of Q9H299, SH3 domain-binding glutamic acid-rich-like protein 3 SH3BGRL3 2 −2.75577 0.0011
  1. Only proteins identified with at least two unique peptides are shown. Up-regulated proteins are shown in the upper part of the table (grey), with Integrin beta-3 showing the highest fold change. Down-regulated proteins are shown in the bottom part of the table (light blue), with Isoform of Q9H299, SH3 domain-binding glutamic acid-rich-like protein 3, showing the highest fold change of all down-regulated proteins