Fig. 2
From: Functional alterations of myeloid cells during the course of Alzheimer’s disease
Monocyte populations shift as AD burden increases. Monocyte population changes via flow cytometric analysis of CD14 and CD16 expression on HLADR+ myeloid immune cells. Decreases in (a) classical monocytes (CD14+ CD16-) with increasing disease burden with a redistribution of monocytes into (b) intermediate (CD14+ CD16+) and (c) non-classical populations (CD14low CD16+). Numbers shown as averages ± SEM and with one-way ANOVA with Tukey’s post hoc analysis (Control n = 35, CDR0.5 n = 31, CDR1 n = 18, CDR2/3 n = 17). Increased MDSC populations (d) in CDR0.5 and CDR1 patients compared with controls as percent of total CD14 cell population. MDSC numbers fall to control levels in CDR2/3 patients (Control n = 32, CDR0.5 n = 28, CDR1 n = 17, CDR2/3 n = 13). Numbers shown as averages ± SEM and with one-way ANOVA with Tukey’s post hoc test. P-values are *p < 0.05, **p < 0.01, and ***p < 0.001