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Table 1 Summary of the major findings on TREM2 in AD context

From: New insights into the role of TREM2 in Alzheimer’s disease

AD context Major TREM2-AD related findings Source Citations
Risk factors ❖ Rare variants in TREM2 increase LOAD risk by 2- to 4- fold AD patients [104, 107,108,109,110,111,112,113,114,115,116,117,118]
Amyloid pathology ❖ Loss of functional TREM2 decreases microgliosis around plaques 5xFAD mice APPPS1-21 mice [45, 75, 130, 132, 133]
❖ Loss of functional TREM2 decreases plaque compaction 5xFAD mice APPPS1-21 mice [75, 89, 90, 133]
Tau pathology ❖ TREM2 deletion decreases tau-mediated neurodegeneration PS19 mice [152, 153]
❖ TREM2 deletion (1) or haploinsuficiency (2) increase tau pathology hTau mice (1) PS19 mice (2) [151] (1) [153] (2)
ApoE ❖ ApoE is a TREM2 ligand in vitro [76, 78, 79]
❖ ApoE-induced switch from homeostatic to neurodegenerative microglia is TREM2-dependent APPPS1-21 mice [95]