Fig. 9
From: Glucose transporter 1 critically controls microglial activation through facilitating glycolysis
The effect of STF31 on light-induced photoreceptor degeneration and microglial activation. CX3CR1gfp/+ mice were exposed to 50,000 lx focal white light for 10 min with daily STF31 or vehicle (DMSO) treatment. Eyes were collected 4 days after light exposure. a-d Representative confocal images showing cone arrestin-positive cells in control (a), light-exposed (b), light + STF31 (c) and light + DMSO (d) mice. e Graph showing the number of cone photoreceptors in different groups of mice. f-i Representative confocal images showing GFP-positive retinal microglia in normal (f), light-exposed (g), light + STF31 (h) and light + DMSO (I) mice. j Graph showing the average number of cross points of microglia in different groups of mice. Mean ± SEM. A minimum of 6 images was taken from each retina. Full control, n = 4 mice, n = 6 mice in other groups. * P < 0.05; ***P < 0.001. Scale bar: 50 μm