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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Fig. 7

Mislocalization of RanGAP1 in (G4C2)149–mice. a Representative images of immunohistochemical analysis of RanGAP1 in the cortex of (G4C2)2 and (G4C2)149 mice at 3 and 12 months of age, with nuclear invaginations indicated by black arrowheads. b Quantitative analysis of the number of RanGAP1-positive nuclear invaginations per mm2 of cortex. Data represent the mean ± SEM. **p < 0.01, ****p < 0.0001 as analyzed by 2-way ANOVA followed by Tukey’s post-hoc analysis. Scale bar represents 20 μm

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