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Table 1 Comorbidities in 1153 Patients with Pathologic Diagnosis of AD. The majority of AD cases were observed to have pathologic comorbidities as observed in the Mayo Clinic Brain Bank 2007–2016. Plus sign (+) in the column on pathological diagnosis of AD indicates additional pathologies beyond the primary and secondary diagnoses listed. Bold indicates significance from the pure AD cases (Student t-Test, p < 0.01)

From: The neuropathological diagnosis of Alzheimer’s disease

Pathological Dx Cases (n) Age (yr) Brain (g) Braak Thal
AD 243 76.5 ± 10.8 1077 ± 159 5.5 ± 0.7 4.7 ± 0.6
AD/LBD 175 76.0 ± 10.2 1053 ± 151 5.6 ± 0.6 4.8 ± 0.6
AD/LBD+ 206 81.8 ± 9.3 1025 ± 170 5.6 ± 0.6 4.8 ± 0.5
AD/Vas 113 84.5 ± 7.9 1070 ± 164 5.3 ± 0.8 4.6 ± 0.8
AD/Vas+ 77 86.0 ± 6.4 1043 ± 142 5.3 ± 0.7 4.8 ± 0.6
AD/CAA 42 76.1 ± 11.6 1089 ± 163 5.6 ± 0.6 4.6 ± 0.6
AD/CAA+ 110 80.1 ± 9.0 1086 ± 163 5.6 ± 0.6 4.7 ± 0.7
AD/HpScl 27 86.0 ± 6.9 1088 ± 158 5.4 ± 0.7 5.0 ± 0.0
AD/HpScl+ 51 87.8 ± 6.9 1012 ± 174 5.4 ± 0.7 4.8 ± 0.6
AD/Other 59 79.3 ± 10.9 1044 ± 164 5.4 ± 0.8 4.7 ± 0.7
AD/Other+ 50 81.9 ± 11.2 1019 ± 186 5.3 ± 0.8 4.5 ± 0.8