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Table 3 Pathologic Diagnoses in 626 Patients with Clinical Diagnosis of AD. The majority of clinical AD cases as observed in the Mayo Clinic Brain Bank from 2007 to 2016 were found to have co-pathologies. Plus sign (+) in the column on pathological diagnosis of AD indicates additional pathologies beyond the primary and secondary diagnoses listed. Secondary AD indicates a primary pathological diagnosis other than Alzheimer’s disease though AD changes are noted and contributing. Bold indicates significance differences from the pure AD cases (Student t-Test, p < 0.01)

From: The neuropathological diagnosis of Alzheimer’s disease

Path Dx Cases (n) Age (yr) Brain (g) Braak Thal
AD 108 77.3 ± 11.2 1060 ± 166 5.6 ± 0.7 4.7 ± 0.7
AD/LBD 73 79.2 ± 9.7 1017 ± 122 5.7 ± 0.5 4.9 ± 0.5
AD/LBD+ 104 83.1 ± 8.3 981 ± 168 5.6 ± 0.6 4.8 ± 0.6
AD/Vas 41 84.4 ± 5.0 1007 ± 148 5.4 ± 0.8 4.6 ± 0.7
AD/Vas+ 46 86.9 ± 6.6 1052 ± 135 5.2 ± 0.6 4.8 ± 0.5
AD/CAA 17 75.3 ± 14.8 1019 ± 146 5.8 ± 0.4 4.8 ± 0.4
AD/CAA+ 53 80.3 ± 9.1 1045 ± 156 5.6 ± 0.5 4.7 ± 0.8
AD/HpScl 20 86.7 ± 5.8 1104 ± 143 5.5 ± 0.6 5.0 ± 0.0
AD/HpScl+ 24 87.3 ± 7.5 977 ± 181 5.7 ± 0.6 5.0 ± 0.0
AD/Other 21 80.9 ± 11.0 1032 ± 135 5.5 ± 0.6 4.8 ± 0.6
AD/Other+ 25 81.8 ± 10.6 950 ± 176 5.4 ± 0.7 4.6 ± 0.7
Secondary AD 15 79.5 ± 8.1 1075 ± 167 4.6 ± 0.9 4.4 ± 0.9
No AD 74 83.0 ± 7.7 1049 ± 167 2.9 ± 1.3 1.5 ± 1.7
Normal 5 87.6 ± 4.5 1140 ± 158 2.9 ± 0.2 1.4 ± 1.3