Skip to main content
Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

Fig. 7

Significant increase in LacCer and GM3 levels, but significant decrease in complex ganglioside levels in CSF of PD patients. Ante-mortem CSF from control subjects (n = 15) and age-matched PD patients (n = 28) was used to determine LacCer (a), GA2 (b), GM3 (c), GM2 (d), GD3 (e), GM1a (f), GD1a (g), GD1b (h), and GT1b (i) levels with NP-HPLC (* = p < 0.05, ** = p < 0.01, *** = p < 0.001, unpaired t-test). j Total ganglioside levels (sum of GM1a, GD1a, GD1b and GT1b) in ante-mortem CSF from control subjects and PD patients (** = p < 0.01, unpaired t-test). Data are presented as mean ± SD

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326