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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Fig. 2

Loss of NRBF2 causes memory and LTP deficits in mice. a Discrimination ratio obtained from OLT task. Results are mean ± SEM of 3 months old WT (n = 15) and KO (n = 14) mice. b Freezing behavior recorded during CFC experiments. Results are mean ± SEM of 3 months old WT (n = 12) and KO (n = 10) mice. c Percentage of errors measured during RAM experiments. Results are mean ± SEM of3 months old WT (n = 15) and KO (n = 14) mice. The statistical significance was determined using row-matched two-way ANOVA test followed by Bonferroni’s post-test. d fEPSP slope measured from Schaffer collateral path. Results are mean ± SEM of 3 months old WT (n = 6) and KO (n = 6) slices from three different mice per group. The statistical significance was determined using regular two-way ANOVA on the last hour of recording. e Basal synaptic transmission measured from WT and KO mice. Results are mean ± SEM of 3 months old WT (n = 3) and KO (n = 3) slices from three different mice per group

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