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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

Fig. 4

αSyn expression affects mitochondrial dynamics and can be rescued with AICAR. a Representative cropped western blot showing DRP1 in cytosol and mitochondria from H4 SL1&SL2 cells over time (0 – 72 h). Quantitation of protein levels for DRP1 in cytosol and mitochondria (n = 3). DRP1 band was normalized to respective loading controls GAPDH and COXIV. b Representative cropped western blot from showing DRP1and p-DRP1 levels in cells treated with or without AICAR (n = 4). Error bars represent the mean ± SD. *p < 0.05, **p < 0.01

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