Fig. 7
From: Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
SIRT3 is decreased in human post-mortem brain of neuropathologically confirmed Lewy body disease individuals. a Representative cropped western blot from n = 3 showing decreased SIRT3 in total brain lysates from ten LBD brains compared to ten age-matched healthy controls. b Quantification of αsyn, SIRT3 protein levels from n = 3 western blots. c, d Representative western blot of cytosolic fraction. DRP1 and αsyn were quantified using GAPDH as a loading control. e, f Representative western blot of mitochondrial fraction. DRP1 and αsyn were quantified using COXIV as a loading control. Error bars represent the mean ± SD. **p < 0.01