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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Fig. 1

Pharmacological chaperone ameliorates behavioral deficits of 3xTg mice. a Number of total arm entries for wild-type mice (WT) and 3xTg mice (3xTg) treated with TPT or control (WT, 3xTg). b Percentage of alternations for WT and 3xTg mice treated with TPT or control. c Contexual fear memory response in WT and 3xTg mice treated with TPT or control. d Cued fear memory response in WT and 3xTg mice treated with TPT or control. e Morris water maze, probe trial for the same four groups of mice, number of entries to the platform area; f Morris water maze, probe trial for the same four groups of mice, latency to first entry to the platform area. Values represent mean ± standard error of the mean (*p < 0.05, WT Control vs WT/TPT; #p < 0.05, WT Control vs 3xTg Control; ^p < 0.05, 3xTg Control vs 3xTg/TPT). (WT Control: n = 10; WT/TPT: n = 8; 3xTg Control, n = 8; 3xTg/TPT, n = 8)

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Molecular Neurodegeneration

ISSN: 1750-1326