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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Fig. 2

Pharmacological chaperone affects retromer complex levels in 3xTg mice. a Representative western blot analysis of VPS35, VPS26, VPS29, Cl-MPR and CTSD proteins in brain cortex homogenates from wild type (WT) and 3xTg mice treated with TPT or control (WT, 3xTg). b Densitometry of the immunoreactivities shown in the previous panel. Values represent mean ± standard error of the mean (*p < 0.05, WT Control vs WT/TPT, n = 3; #p < 0.05, WT Control vs 3xTg Control, n = 3; ^p < 0.05, 3xTg Control vs 3xTg/TPT, n = 3). c. Representative images of brain cortex sections of 3xTg receiving vehicle (3xTg) or TPT (3xTg/TPT) immunostained for VPS35 (scale bar 10 μm). d Quantification of the immune-fluorescent signal for VPS35 as observed in the previous panel. Values represent mean ± standard error of the mean (*p < 0.05 n = 3 per group)

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Molecular Neurodegeneration

ISSN: 1750-1326