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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

Fig. 4

Overlaps between strain-associated mouse modules and human AMP-AD modules. a Mouse modules significantly driven by one or more of Apoe−/−, APOEε4, APP/PS1, Cd2ap+/− and Clu−/− mouse strains. The horizontal scale bar represents the average eigengene expression of mouse strains in mouse modules. b Overlaps between mouse modules and 30 human AMP-AD modules. The vertical scale bar represents Jaccard indices between mouse modules and AMP-AD modules. Jaccard indices were computed between each mouse and AMP-AD human modules

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Molecular Neurodegeneration

ISSN: 1750-1326