Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

An, Yu; Zhang, Xiaona; Wang, Ying; Wang, Yushan; Liu, Wen; Wang, Tao; Qin, Zhongsheng; Xiao, Rong

doi:10.1186/s13024-019-0353-1

Molecular Neurodegeneration

Table 7 Subanalysis for results of mixed-effects regression models predicting cognitive test performance from dietary cholesterol and egg intake by different educational groups

From: Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

Cognitive tests	Dietary cholesterol2		Dietary cholesterol		Egg intake2		Egg intake
Cognitive tests	β	P value	β	P value	β	P value	β	P value
Elementary school (n = 418)
MoCA	0.00000347	0.257	−0.004239	0.102	0.0000902	0.202	−0.020563	0.048*
AVLT-IR	−0.00000105	0.746	−0.001233	0.654	0.0000432	0.56	−0.017803	0.107
AVLT-SR	0.00000115	0.501	−0.002667	0.067	0.0000348	0.375	−0.013017	0.026*
AVLT-LR	0.000000766	0.693	−0.002141	0.193	0.0000178	0.689	−0.011021	0.095
SDMT	0.00000511	0.519	−0.001092	0.87	0.0001744	0.342	−0.009431	0.726
DSF	0.000000705	0.537	−0.000568	0.557	0.00000138	0.958	−0.001005	0.796
LMT	0.00000044	0.933	−0.002083	0.641	0.0000577	0.624	−0.017358	0.328
Junior middle school (n = 925)
MoCA	−0.00000223	0.064	0.002945	0.011*	−0.0000345	0.167	0.0077031	0.087
AVLT-IR	−0.00000349	0.062	0.004374	0.015*	−0.0000191	0.622	0.0079525	0.255
AVLT-SR	−0.00000199	0.038*	0.001977	0.032*	−0.0000191	0.336	0.0032397	0.366
AVLT-LR	−0.00000158	0.136	0.001501	0.138	−0.00000175	0.936	0.0001187	0.976
SDMT	−0.0000127	0.002*	0.010674	0.005*	−0.0001801	0.030*	0.0240724	0.108
DSF	−0.000000446	0.378	0.000669	0.167	−0.000023	0.028*	0.0051033	0.007*
LMT	−0.00000132	0.553	0.003593	0.091	−0.0000423	0.357	0.013091	0.114
Senior middle school (n = 764)
MoCA	−0.00000155	0.075	0.002437	0.013*	−0.00000089	0.988	0.0045697	0.483
AVLT-IR	−0.00000141	0.336	0.002893	0.078	0.0000611	0.521	−0.001338	0.902
AVLT-SR	−0.00000127	0.091	0.000801	0.342	−0.00000153	0.975	− 0.001089	0.845
AVLT-LR	−0.00000132	0.112	0.000674	0.47	−0.0000122	0.822	0.0005769	0.926
SDMT	−0.0000018	0.606	0.002899	0.459	0.00000761	0.973	0.0012421	0.962
DSF	−0.000000936	0.011*	0.001025	0.013*	− 0.0000315	0.184	0.0068822	0.011*
LMT	−0.00000268	0.183	0.002725	0.226	0.0000091	0.944	0.0061439	0.679
College and above (n = 407)
MoCA	−0.0000011	0.511	0.001583	0.309	−0.0001057	0.052	0.0134549	0.053
AVLT-IR	−0.00000213	0.544	0.001039	0.75	− 0.0002722	0.016*	0.0243167	0.092
AVLT-SR	0.000000363	0.839	0.000177	0.915	−0.0000809	0.16	0.0097477	0.186
AVLT-LR	0.000000472	0.811	0.000178	0.923	−0.0000889	0.162	0.0101086	0.214
SDMT	0.00000371	0.662	−0.005496	0.486	− 0.0000766	0.778	− 0.012119	0.728
DSF	−0.000000251	0.782	−0.000251	0.766	−0.0000345	0.241	0.0033226	0.378
LMT	0.00000291	0.47	−0.001744	0.639	−0.0001277	0.332	0.0196316	0.242

Abbreviations: MoCA Montreal Cognitive Assessment, AVLT-IR auditory verbal learning test-immediate recall, AVLT-SR auditory verbal learning test-short recall, AVLT-LR auditory verbal learning test-long recall, SDMT symbol digit modalities test, DSF digit span forwards, LMT logical memory test
β: unstandardized regression coefficients were obtained from mixed-effects regression models adjusted for sex, age, BMI, smoking and drinking status, diabetes, hypertension and coronary artery disease history and per se use of lipid-lowering medication, number of APOE ε4 alleles and intakes of energy, protein, carbohydrates, fat, SFA, PUFA, and MUFA
Elementary school: ≤6 years of education; Junior middle school: 7–9 years of education; Senior middle school: 10–12 years of education; College and above: at least college or university; ≥13 years of education)
∗P < 0.05

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ISSN: 1750-1326

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