Fig. 1

Alteration of gene expression in Lrrk2^−/− striatal neurons during aging. a The volcano plots of RNA-seq data collected from the dorsal striatum of Lrrk2^+/+ and Lrrk2^−/− mice at 2 months (n = 3 and 4 for the Lrrk2^+/+ and Lrrk2^−/− mice, respectively) and 12 months (n = 3 mice per genotype) of age. Adjusted p < 0.05, log₂FD > 1. b-d GO enrichment analysis for the data collected from the Lrrk2^+/+ and Lrrk2^−/− mice at 2 months (b) and 12 months of age (c) using DAVID. Adjusted p < 0.05. Supervised clustering for the data collected from the 12-month-old Lrrk2^+/+ and Lrrk2^−/− mice (d). e The upregulated genes of the 2-month-old Lrrk2^−/− mice showed a decreased trend when calculated again at 12 months of age. In contrast, the downregulated genes display a significant enhancement during aging. Paired t-test, ^*p = 0.0131. f The upregulated genes are more common in the 2-month-old Lrrk2^−/− samples. The downregulated genes occur more often in the 12-month-old Lrrk2^−/− samples