Fig. 6

Lrrk2^−/− mice developed age-dependent motor abnormalities. a, b The travel distance (a) and average speed (b) of Lrrk2^+/+ and Lrrk2^−/− mice at 3 (n = 10 and 12 for Lrrk2^+/+ and Lrrk2^−/− mice, respectively), 12 (n = 10 and 11 for Lrrk2^+/+ and Lrrk2^−/− mice, respectively) and 24 months of age (n = 12 mice per genotype). 2way ANOVA analysis with Sidak’s multiple comparisons test, ^***p = 0.0008 (travel distance), ^***p = 0.0008 (average speed). c Accumulative (Accum.) frequency of speed distribution in Lrrk2^+/+ and Lrrk2^−/− mice at 3 months, 12 months and 24 months of age. d The latency to fall from rotarod was recorded from the same cohorts of Lrrk2^+/+ and Lrrk2^−/− mice at 3, 12 and 24 months of age. 2way ANOVA analysis with Sidak’s multiple comparisons test at 12 months, ^*p = 0.0308 (day 5), ^*p = 0.0266 (day 6). 2way ANOVA analysis with Sidak’s multiple comparisons test at 24 months, ^*p = 0.016 (day 3), ^*p = 0.0124 (day 6)