Fig. 7
From: α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment
Nilotinib (Nilo) treatment reduces neuronal accumulation of pS129αS, activated c-Abl, activated p53, and p62. Paraffin embedded sagittal brain sections from Nilo and DMSO treated end-stage TgA53T mice were used for immunofluorescence co-localization of pS129αS with p62 (a), pY245c-Abl (b) and pS15p53 (c). Shown are the brainstem regions. The results show that Nilo treatment leads to reduced neuronal accumulation of pS129αS (a-c), p62 (a), pY245c-Abl (b), and pS15p53 (c). Scale bar, 20 μm