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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: A role for α-Synuclein in axon growth and its implications in corticostriatal glutamatergic plasticity in Parkinson’s disease

Fig. 8

Illustrative synopsis. α-Syn enriches axon membrane with the acidic phosphoinositide PI4,5P2 to facilitate axon outgrowth and arborization. In brains affected with PD, over expression or mutations in α-Syn increase axon density at early stages of the disease and enhance glutamatergic plasticity in caudal white matter tracts (WMTs). However, with disease progression, accumulation of damage is leading to degeneration and loss of axons within WMTs

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Molecular Neurodegeneration

ISSN: 1750-1326