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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice

Fig. 8

Different lipid profiles in lysosomal and whole-cell membranes from APOE4 vs APOE3 astrocytes. a Cholesterol accumulation visualized by Filipin III staining in immortalized APOE3 and APOE4 astrocytes (N = 2). Scale bar represents 100 μm. The white squares are amplified in the top right images. b, c PLS-DA analysis of lysosomal (b) and whole-cell membranes (c) from APOE3 and APOE4 immortalized astrocytes. Each dot is an individual sample. d, e Representation of changes of lipids with VIP > 1 identified in lysosome (d) and whole-cell (e) membranes as logarithm base 2 of fold changes of intensities in APOE4 vs APOE3. Positive values indicate increase and negative values decrease in APOE4 vs APOE3 cells. q < 0.05 (*), q < 0.01 (**), multi T-test analysis corrected by false discovery rate (FDR)

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