Table 1 Relationship between BIN1 peptides and cognitive decline is not independent of APOEε4. The tables present regressions results of BIN1 peptides and count of APOEε4 alleles (0, 1, or 2) after adjustement for age at death, sex and cohort (ROS/MAP)
Effect of APOE휺4 on cognitive decline | |||
Beta | p | r2 | |
-0.0446 | 3.37E-34 | 0.0571 | |
Effect of BIN1 peptide on cognitive decline | |||
peptide | Beta | p | r2 |
LQAHLVAQTNLLR | 0.0564 | 4.63E-05 | 0.0148 |
NQAEEELIK | 0.0775 | 7.34E-06 | 0.0179 |
AAPQWCQGK | 0.0287 | 0.013 | 0.00553 |
AEEELIK | -0.00473 | 0.134 | 0.00201 |
AQPSDNAPAK | -0.00497 | 0.254 | 0.00117 |
VNHEPEPAGGATPGATLPK | -0.00547 | 0.365 | 0.000736 |
GPPVPPPPK | 0.0262 | 0.0605 | 0.00315 |
Effect of APOE휺4 on cognitive decline after adjustment with BIN1 peptide | |||
peptide | Beta | p | r2 |
LQAHLVAQTNLLR | -0.0508 | 2.23E-16 | 0.059710486 |
NQAEEELIK | -0.051 | 1.10E-16 | 0.06085979 |
AAPQWCQGK | -0.0519 | 2.65E-17 | 0.063426582 |
AEEELIK | -0.0526 | 1.39E-17 | 0.064351255 |
AQPSDNAPAK | -0.0526 | 1.78E-17 | 0.064331654 |
VNHEPEPAGGATPGATLPK | -0.0528 | 1.20E-17 | 0.064654118 |
GPPVPPPPK | -0.0532 | 5.21E-18 | 0.065998496 |
Effect of BIN1 peptide on cognitive decline after adjustment with APOE휺4 | |||
peptide | Beta | p | r2 |
LQAHLVAQTNLLR | 0.0391 | 0.00386 | 7.60E-03 |
NQAEEELIK | 0.0595 | 0.000392 | 1.14E-02 |
AAPQWCQGK | 0.0238 | 0.0325 | 4.18E-03 |
AEEELIK | -0.00275 | 0.366 | 7.46E-04 |
AQPSDNAPAK | -0.000636 | 0.88 | 2.08E-05 |
VNHEPEPAGGATPGATLPK | -0.00202 | 0.73 | 1.09E-04 |
GPPVPPPPK | 0.0302 | 0.0247 | 4.59E-03 |