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Table 1 Relationship between BIN1 peptides and cognitive decline is not independent of APOEε4. The tables present regressions results of BIN1 peptides and count of APOEε4 alleles (0, 1, or 2) after adjustement for age at death, sex and cohort (ROS/MAP)

From: BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology

Effect of APOE휺4 on cognitive decline
  Beta p r2
  -0.0446 3.37E-34 0.0571
Effect of BIN1 peptide on cognitive decline
peptide Beta p r2
 LQAHLVAQTNLLR 0.0564 4.63E-05 0.0148
 NQAEEELIK 0.0775 7.34E-06 0.0179
 AAPQWCQGK 0.0287 0.013 0.00553
 AEEELIK -0.00473 0.134 0.00201
 AQPSDNAPAK -0.00497 0.254 0.00117
 VNHEPEPAGGATPGATLPK -0.00547 0.365 0.000736
 GPPVPPPPK 0.0262 0.0605 0.00315
Effect of APOE휺4 on cognitive decline after adjustment with BIN1 peptide
peptide Beta p r2
 LQAHLVAQTNLLR -0.0508 2.23E-16 0.059710486
 NQAEEELIK -0.051 1.10E-16 0.06085979
 AAPQWCQGK -0.0519 2.65E-17 0.063426582
 AEEELIK -0.0526 1.39E-17 0.064351255
 AQPSDNAPAK -0.0526 1.78E-17 0.064331654
 VNHEPEPAGGATPGATLPK -0.0528 1.20E-17 0.064654118
 GPPVPPPPK -0.0532 5.21E-18 0.065998496
Effect of BIN1 peptide on cognitive decline after adjustment with APOE휺4
peptide Beta p r2
 LQAHLVAQTNLLR 0.0391 0.00386 7.60E-03
 NQAEEELIK 0.0595 0.000392 1.14E-02
 AAPQWCQGK 0.0238 0.0325 4.18E-03
 AEEELIK -0.00275 0.366 7.46E-04
 AQPSDNAPAK -0.000636 0.88 2.08E-05
 VNHEPEPAGGATPGATLPK -0.00202 0.73 1.09E-04
 GPPVPPPPK 0.0302 0.0247 4.59E-03
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